产品货号：
Z36374
中文名称：
RAN抗体
英文名称：
Anti-RAN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RAN Antibody |
| 指标别名 | ARA24;Gsp1;GTPase Ran;RAN;Ras like protein TC4;Ras related nuclear protein;TC4 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,IP,FCM |
| 基因名称 | RAN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human Ran GTP-binding protein involved in nucleocytoplasmic transport.Required for the import of protein into the nucleus and also for RNA export.Involved in chromatin condensation and control of cell cycle (By similarity). |
| 实际分子量 | 24KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex.The RAN protein is also involved in control of DNA synthesis and cell cycle progression.Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1).Mutations in RAN disrupt DNA synthesis.Because of its many functions,it is likely that RAN interacts with several other proteins.RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules.RAN could be a key signaling molecule regulating microtubule polymerization during mitosis.RCC1 generates a high local concentration of RAN-GTP around chromatin which,in turn,induces the local nucleation of microtubules.RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor.Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy).RAN coactivation of the AR diminishes with polyglutamine expansion within the AR,and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. |
| Uniprot ID | P62826 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
相关搜索：RAN抗体，RAN单抗，Anti-RAN Antibody